https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45018 p < 0.001). There was a significant interaction between diagnosis and time in brain development (p < 0.001). This was expressed by a decrease in structural connectivity within the frontoparietal network—and its broader connectivity—in ASD during adolescence and early adulthood. Conversely, these connections increased with time in TDC. Crucially, stronger baseline connectivity in this subnetwork predicted a lower symptom load at follow-up (p = 0.048), independent of the expression of symptoms at baseline. Our findings suggest a clinically meaningful relationship between the atypical development of frontoparietal structural connections and the dynamics of the autism phenotype through early adulthood. These results highlight a potential marker of future outcome.]]> Wed 26 Oct 2022 10:17:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45015 Wed 26 Oct 2022 10:10:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40874 Tue 07 Nov 2023 15:52:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52650 0.66). Conversely, dorsal putamen showed reduced modulation over lateral prefrontal cortex activity (Pp > 0.90). These functional deregulations emerged on top of a generally intact anatomical substrate. We provide out-of-sample replication of opposite changes in ventro-anterior and dorso-posterior frontostriatal connectivity in OCD and advance the understanding of the neural underpinnings of these functional perturbations. These findings inform the development of targeted therapies normalizing frontostriatal dynamics in OCD.]]> Thu 19 Oct 2023 15:19:31 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52651 Thu 19 Oct 2023 15:18:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42303 Fri 17 May 2024 16:00:48 AEST ]]>